the lab

 

  1. Martinez-Estrada, O.M.; Lettice, L.A.; Essafi, A.; Guadix, J.A.; Slight, J.; Velecela, V.; Hall, E.; Reichmann, J.; Devenney, P.S.; Hohenstein, P.; Hosen, N.; Hill, R.E.; Munoz-Chapuli, R. and Hastie, N.D. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin
    Nat.Genet. 42(1):89-93, 2010
    PubMed Abstract
  2. Maslon, M.M. and Hupp, T.R. Drug discovery and mutant p53.
    Trends Cell Biol     20(9):542-555, 2010
    PubMed Abstract
  3. Maslon, M.M.; Hrstka, R.; Vojtesek, B. and Hupp, T.R. A Divergent Substrate-Binding Loop within the Pro-oncogenic Protein Anterior Gradient-2 Forms a Docking Site for Reptin.
    J Mol.Biol     404(3):418-438, 2010
    PubMed Abstract
  4. McCullough, B.J.; Kalapothakis, J.M.; Chin, W.; Taylor, K.; Clarke, D.J.; Eastwood, H.; Campopiano, D.; MacMillan, D.; Dorin, J. and Barran, P.E. Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements. Phys.Chem.Chem.Phys. 12(14):3589-3596, 2010
    PubMed Abstract
  5. Michlewski, G. and Caceres, J.F. Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.
    Nat.Struct.Mol.Biol 17(8):1011-8, 2010
    PubMed Abstract
  6. Michlewski, G. and Caceres, J.F. RNase-assisted RNA chromatography.
    RNA     16(8):1673-1678, 2010
    Pubmed Abstract
  7. Mitchell, K.J. and Porteous, D.J. Rethinking the genetic architecture of schizophrenia. Psychol.Med:1-14, 2010
    PubMed Abstract
  8. Mitry, D.; Fleck, B.W.; Wright, A.F.; Campbell, H. and Charteris, D.G. Pathogenesis of rhegmatogenous retinal detachment: predisposing anatomy and cell biology.
    Retina 30(10):1561-1572, 2010
    PubMed Abstract
  9. Mort, R.L.; Hay, L. and Jackson, I.J. Ex-vivo live imaging of melanoblast migration in embryonic mouse skin. Pigment Cell Melanoma Res 23(2):229-301, 2010
    PubMed Abstract
  10. Morton, J.P.; Timpson, P.; Karim, S.A.; Ridgway, R.A.; Athineos, D.; Doyle, B.; Jamieson, N.B.; Oien, K.A.; Lowy, A.M.; Brunton, V.G.; Frame, M.C.; Evans, T.R. and Sansom, O.J. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc.Natl.Acad.Sci.U.S.A 107(1):246-251, 2010
    PubMed Abstract
  11. Muller, I.; Boyle, S.; Singer, R.H.; Bickmore, W.A. and Chubb, J.R. Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells.
    PLoS One.     5(7):e11560, 2010
    PubMed Abstract
  12. Navarro, P.; Vitart, V.; Hayward, C.; Tenesa, A.; Zgaga, L.; Juricic, D.; Polasek, O.; Hastie, N.D.; Rudan, I.; Campbell, H.; Wright, A.F.; Haley, C.S. and Knott, S.A. Genetic comparison of a Croatian isolate and CEPH European founders. Genet.Epidemiol 34(2):140-5, 2010
    PubMed Abstract
  13. Nestor, C.; Ruzov, A.; Meehan, R.R. and Dunican, D.S. Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethlcytosine in DNA. BioTechniques 48(4):317-319, 2010 PubMed Abstract
  14. Nicholson, J. and Hupp, T.R. The molecular dynamics of MDM2. Cell Cycle 9(10), 2010 PubMed Abstract
  15. O'Dushlaine, C.; McQuillan, R.; Weale, M.E.; Crouch, D.J.; Johansson, A.; Aulchenko, Y.; Franklin, C.S.; Polasek, O.; Fuchsberger, C.; Corvin, A.; Hicks, A.A.; Vitart, V.; Hayward, C.; Wild, S.H.; Meitinger, T.; van Duijn, C.M.; Gyllensten, U.; Wright, A.F.; Campbell, H.; Pramstaller, P.P.; Rudan, I. and Wilson, J.F. Genes predict village of origin in rural Europe. Eur.J Hum.Genet.18(11), 1269-70, 2010
    PubMed Abstract
  16. Ollinger, R.; Reichmann, J. and Adams, I.R. Meiosis and retrotransposon silencing during germ cell development in mice.
    Differentiation     79(3):147-158, 2010
    PubMed Abstract
  17. Overton, I.M.; van Niekerk, C.A. and Barton, G.J. XANNpred: Neural nets that predict the propensity of a protein to yield diffraction-quality crystals.
    Proteins     e-pub Oct 19, 2010
    PubMed Abstract
  18. Paige, A.J.; Zucknick, M.; Janczar, S.; Paul, J.; Mein, C.A.; Taylor, K.J.; Stewart, M.; Gourley, C.; Richardson, S.; Perren, T.; Ganesan, T.S.; Smyth, J.F.; Brown, R. and Gabra, H. WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis.
    Eur.J Cancer      46(4):818-825, 2010
    PubMed Abstract
  19. Pattaro, C.; De Grandi, A.; Vitart, V.; Hayward, C.; Franke, A.; Aulchenko, Y.S.; Johansson, A.; Wild, S.H.; Melville, S.A.; Isaacs, A.; Polasek, O.; Ellinghaus, D.; Kolcic, I.; Nothlings, U.; Zgaga, L.; Zemunik, T.; Gnewuch, C.; Schreiber, S.; Campbell, S.; Hastie, N.; Boban, M.; Meitinger, T.; Oostra, B.A.; Riegler, P.; Minelli, C.; Wright, A.F.; Campbell, H.; van Duijn, C.M.; Gyllensten, U.; Wilson, J.F.; Krawczak, M.; Rudan, I. and Pramstaller, P.P. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. BMC Med Genet. 11:41, 2010
    PubMed Abstract
  20. Patton, E.E.; Mitchell, D.L. and Nairn, R.S. Genetic and Environmental Melanoma Models in Fish.
    Pigment Cell Melanoma Res     23:314-337, 2010
    PubMed Abstract
  21. Patton, E.E. and Nairn, R.S. Xmrk in medaka: a new genetic melanoma model.
    J Invest Dermatol.     130(1):14-17, 2010
    PubMed Abstract
  22. Phillips, A.M.; Nimmo, E.R.; Van Limbergen, J.; Drummond, H.E.; Smith, L. and Satsangi, J. Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease.
    Inflamm.Bowel.Dis 16(4):557-558, 2010 PubMed Abstract
  23. Polasek, O.; Hayward, C.; Bellenguez, C.; Vitart, V.; Kolcic, I.; McQuillan, R.; Saftic, V.; Gyllensten, U.; Wilson, J.F.; Rudan, I.; Wright, A.F.; Campbell, H. and Leutenegger, A.L. Comparative assessment of methods for estimating individual genome-wide homozygosity-by-descent from human genomic data. BMC Genomics 11:139, 2010
    Pubmed Abstract
  24. Pucic, M.; Pinto, S.; Novokmet, M.; Knezevic, A.; Gornik, O.; Polasek, O.; Vlahovicek, K.; Wang, W.; Rudd, P.M.; Wright, A.F.; Campbell, H.; Rudan, I. and Lauc, G. Common aberrations from the normal human plasma N-glycan profile. Glycobiology 20(8):970-975, 2010
    PubMed Abstract
  25. Ralston, S.H.; Kou, T.D.; Wick-Urban, B.; Steinbuch, M. and Masud, T. Risk of upper gastrointestinal tract events in risedronate users switched to alendronate.
    Calcif.Tissue Int.     87(4):298-304, 2010
    PubMed Abstract
  26. Ralston, S.H.; Kou, T.D.; Wick-Urban, B.; Steinbuch, M. and Masud, T. Erratum to: Risk of Upper Gastrointestinal Tract Events in Risedronate Users Switched to Alendronate. Calcif.Tissue Int. 87(6):550, 2010
    PubMed Abstract
  27. Ralston, S.H. and Uitterlinden, A.G. Genetics of Osteoporosis. Endocr.Rev. e-pub April 29, 2010 PubMed Abstract
  28. Ralston, S.H. Genetics of osteoporosis. Ann.N.Y.Acad.Sci. 1192(1):181-189, 2010 PubMed Abstract
  29. Ralston, S. H. Osteoporosis as an Heriditary Disease. Clinical Reviews in Bone and Mineral Metabolism. e-pub 1-9, 2010
  30. Ratelade, J.; Arrondel, C.; Hamard, G.; Garbay, S.; Harvey, S.; Biebuyck, N.; Schulz, H.; Hastie, N.; Pontoglio, M.; Gubler, M.C.; Antignac, C. and Heidet, L. A MURINE MODEL OF DENYS-DRASH SYNDROME REVEALS NOVEL TRANSCRIPTIONAL TARGETS OF WT1 IN PODOCYTES.
    Hum.Mol.Genet.     19(1):1-15, 2010
    PubMed Abstract
  31. Rieger, M.E.; Sims, A.H.; Coats, E.R.; Clarke, R.B. and Briegel, K.J. The Embryonic Transcription Cofactor LBH is a Direct Target of the WNT Signaling Pathway in Epithelial Development and in Aggressive Basal Subtype Breast Cancers.
    Mol.Cell Biol 30(17):4267-79, 2010
    PubMed Abstract
  32. Repapi, E.; Sayers, I.; Wain, L.V.; Burton, P.R.; Johnson, T.; Obeidat, M.; Zhao, J.H.; Ramasamy, A.; Zhai, G.; Vitart, V.; Huffman, J.E.; Igl, W.; Albrecht, E.; Deloukas, P.; Henderson, J.; Granell, R.; McArdle, W.L.; Rudnicka, A.R.; Barroso, I.; Loos, R.J.; Wareham, N.J.; Mustelin, L.; Rantanen, T.; Surakka, I.; Imboden, M.; Wichmann, H.E.; Grkovic, I.; Jankovic, S.; Zgaga, L.; Hartikainen, A.L.; Peltonen, L.; Gyllensten, U.; Johansson, A.; Zaboli, G.; Campbell, H.; Wild, S.H.; Wilson, J.F.; Glaser, S.; Homuth, G.; Volzke, H.; Mangino, M.; Soranzo, N.; Spector, T.D.; Polasek, O.; Rudan, I.; Wright, A.F.; Heliovaara, M.; Ripatti, S.; Pouta, A.; Naluai, A.T.; Olin, A.C.; Toren, K.; Cooper, M.N.; James, A.L.; Palmer, L.J.; Hingorani, A.D.; Wannamethee, S.G.; Whincup, P.H.; Smith, G.D.; Ebrahim, S.; McKeever, T.M.; Pavord, I.D.; MacLeod, A.K.; Morris, A.D.; Porteous, D.J.; Cooper, C.; Dennison, E.; Shaheen, S.; Karrasch, S.; Schnabel, E.; Schulz, H.; Grallert, H.; Bouatia-Naji, N.; Delplanque, J.; Froguel, P.; Blakey, J.D.; Britton, J.R.; Morris, R.W.; Holloway, J.W.; Lawlor, D.A.; Hui, J.; Nyberg, F.; Jarvelin, M.R.; Jackson, C.; Kahonen, M.; Kaprio, J.; Probst-Hensch, N.M.; Koch, B.; Hayward, C.; Evans, D.M.; Elliott, P.; Strachan, D.P.; Hall, I.P. and Tobin, M.D. Genome-wide association study identifies five loci associated with lung function.
    Nat.Genet.     42(1):36-44, 2010
    PubMed Abstract
  33. Richardson, L.; Venkataraman, S.; Stevenson, P.; Yang, Y.; Burton, N.; Rao, J.; Fisher, M.; Baldock, R.A.; Davidson, D.R. and Christiansen, J.H. EMAGE mouse embryo spatial gene expression database: 2010 update
    Nucleic Acids Res 38(Database issue):
    D703-D709, 2010
    PubMed Abstract
  34. Riches, P.L. and Ralston, S.H. Recent insights into the biology of bone turnover. Journal of the Royal College of Pysicians Edinburgh 40(1):66-69, 2010
  35. Rieger, M.E.; Sims, A.H.; Coats, E.R.; Clarke, R.B. and Briegel, K.J. The Embryonic Transcription Cofactor LBH is a Direct Target of the WNT Signaling Pathway in Epithelial Development and in Aggressive Basal Subtype Breast Cancers. Mol.Cell Biol e-pub July 6, 2010 PubMed Abstract
  36. Sabine, V.S.; Sims, A.H.; Macaskill, E.J.; Renshaw, L.; Thomas, J.S.; Dixon, J.M. and Bartlett, J.M. Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer Breast Cancer Res Treat. May 18, 2010
    PubMed Abstract
  37. Santibanez, K.M.; Wilson, V.; Cartwright, N.; Cunnington, M.S.; Mathers, J.C.; Bishop, D.T.; Curtis, A.; Dunlop, M.G. and Burn, J. MLH1 Differential allelic expression in mutation carriers and controls.
    Ann.Hum.Genet.     74(6):479-488, 2010
    PubMed Abstract
  38. Schmidt, C.Q.; Herbert, A.P.; Mertens, H.D.; Guariento, M.; Soares, D.C.; Uhrin, D.; Rowe, A.J.; Svergun, D.I. and Barlow, P.N. The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module. J Mol.Biol 395(1):105-122, 2010
    PubMed Abstract
  39. Selfridge, J.; Song, L.; Brownstein, D.G. and Melton, D.W. Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease.
    DNA Repair (Amst) 9(6):653-660, 2010 PubMed Abstract
  40. Semple, F.; Webb, S.; Li, H.N.; Patel, H.B.; Perretti, M.; Jackson, I.J.; Gray, M.; Davidson, D.J. and Dorin, J.R. Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo. Eur.J Immunol. 40(4):1073-1078, 2010 PubMed Abstract
  41. Serrels, B.; Sandilands, E.; Serrels, A.; Baillie, G.; Houslay, M.D.; Brunton, V.G.; Canel, M.; Machesky, L.M.; Anderson, K.I. and Frame, M.C. A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity.
    Curr.Biol     20(12);1086-92, 2010
    PubMed Abstract
  42. Shu, X.; Zeng, Z.; Gautier, P.; Lennon, A.; Gakovic, M.; Patton, E.E. and Wright, A.F. Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes. Hum.Mol.Genet. 19(4):657-670, 2010
    PubMed Abstract
  43. Smith, N.L.; Chen, M.H.; Dehghan, A.; Strachan, D.P.; Basu, S.; Soranzo, N.; Hayward, C.; Rudan, I.; Sabater-Lleal, M.; Bis, J.C.; de Maat, M.P.; Rumley, A.; Kong, X.; Yang, Q.; Williams, F.M.; Vitart, V.; Campbell, H.; Malarstig, A.; Wiggins, K.L.; van Duijn, C.M.; McArdle, W.L.; Pankow, J.S.; Johnson, A.D.; Silveira, A.; McKnight, B.; Uitterlinden, A.G.; Aleksic, N.; Meigs, J.B.; Peters, A.; Koenig, W.; Cushman, M.; Kathiresan, S.; Rotter, J.I.; Bovill, E.G.; Hofman, A.; Boerwinkle, E.; Tofler, G.H.; Peden, J.F.; Psaty, B.M.; Leebeek, F.; Folsom, A.R.; Larson, M.G.; Spector, T.D.; Wright, A.F.; Wilson, J.F.; Hamsten, A.; Lumley, T.; Witteman, J.C.; Tang, W. and O'Donnell, C.J. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.
    Circulation     121(12):1382-1392, 2010
    PubMed Abstract
  44. Song, L.; Winter, A.G.; Selfridge, J. and Melton, D.W. A novel transcript for DNA repair gene Ercc1 in mouse skin.
    Transgenic Res    , e-pub April 21, 2010
    PubMed Abstract
  45. Sotoodehnia, N.; Isaacs, A…...Hayward, C……. Wright, A.F.and Arking, D.E. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
    Nat.Genet.     42(12):1068-1076, 2010
    PubMed Abstract
  46. Speliotes, E.K.; Willer, C.J.; .. Campbell, H.;... Hayward, C.; ... Stephens, J.; Surakka, I.; Swift, A.J.; Tammesoo, M.L.; Tardif, J.C.; Teder-Laving, M.; Teslovich, T.M.; Thompson, J.R.; Thomson, B.; Tonjes, A.; Tuomi, T.; van Meurs, J.B. and van Ommen, G.J. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat.Genet. 42(11):937-948, 2010
    PubMed Abstract
  47. Sudlow, C. Science, chronic fatigue syndrome, and me. BMJ 340(7745):510, 2010
  48. Sudlow, C.; Macleod, M.; Al Shahi, S.R. and Stone, J. Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"
    Science     28(5980):825, 2010
    PubMed Abstract
  49. Taylor, K.J.; Sims, A.H.; Liang, L.; Faratian, D.; Muir, M.; Walker, G.; Kuske, B.; Dixon, J.M.; Cameron, D.A.; Harrison, D.J. and Langdon, S.P. Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.
    Breast Cancer Res     12(3):R39, 2010
    PubMed Abstract
  50. Taylor, K.L.; Grant, N.J.; Temperley, N.D. and Patton, E.E. Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads.
    Cell Commun.Signal.     8:11, 2010
    PubMed Abstract
  51. Tenesa, A.; Theodoratou, E.; Din, F.V.; Farrington, S.M.; Cetnarskyj, R.; Barnetson, R.A.; Porteous, M.E.; Campbell, H. and Dunlop, M.G. Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.
    Clin Cancer Res 16(14):3754-3759, 2010 PubMed Abstract
  52. Teslovich, T.M.; Musunuru, K.;.....
    Wright, A.F.;.....Vitart, V.;.....
    Hayward, C.;...Hastie, N.D... and Kathiresan, S. Biological, clinical and population relevance of 95 loci for blood lipids.
    Nature     466(7307):707-713, 2010
    PubMed Abstract
  53. Theodoratou, E.; Din, F.V.; Farrington, S.M.; Cetnarskyj, R.; Barnetson, R.A.; Porteous, M.E.; Dunlop, M.G.; Campbell, H. and Tenesa, A. Association between common mtDNA variants and all-cause or colorectal cancer mortality. Carcinogenesis 31(2):296-301, 2010
    PubMed Abstract
  54. Thoms, H.C.; Loveridge, C.J.; Simpson, J.; Clipson, A.; Reinhardt, K.; Dunlop, M.G. and Stark, L.A. Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination
    Cancer Res 70(1):139-149, 2010
    PubMed Abstract
  55. Tong, P.; Prendergast, J.G.; Lohan, A.J.; Farrington, S.M.; Cronin, S.; Friel, N.; Bradley, D.G.; Hardiman, O.; Evans, A.; Wilson, J.F. and Loftus, B. Sequencing and analysis of an Irish human genome. Genome Biol 11(9):R91, 2010
    PubMed Abstract
  56. Tyrrell, C.; De Cecco, M.; Reynolds, N.L.; Kilanowski, F.; Campopiano, D.; Barran, P.; MacMillan, D. and Dorin, J.R. Isoleucine/leucine(2) is essential for chemoattractant activity of beta-defensin Defb14 through chemokine receptor 6
    Mol. Immunol. 47(6):1378-1382, 2010
    PubMed Abstract
  57. van Agtmael, T.; Bailey, M.A.; Schlotzer-Schrehardt, U.; Craigie, E.; Jackson, I.J.; Brownstein, D.G.; Megson, I.L. and Mullins, J.J. Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume.
    Hum.Mol.Genet. 19(6):1119-1128, 2010 PubMed Abstract
  58. Vitart, V.; Bencic, G.; Hayward, C.; Herman, J.S.; Huffman, J.E.; Campbell, S.; Bucan, K.; Zgaga, L.; Kolcic, I.; Polasek, O.; Campbell, H.; Wright, A.F.; Vatavuk, Z. and Rudan, I. Heritabilities of ocular biometrical traits in 2 Croatian isolates with extended pedigrees. Invest Ophthalmol Vis Sci.51(2):737-43, 2010
    PubMed Abstract
  59. Vitart, V.; Bencic, G.; Hayward, C.; Skunca, H.J.; Huffman, J.; Campbell, S.; Bucan, K.; Navarro, P.; Gunjaca, G.; Marin, J.; Zgaga, L.; Kolcic, I.; Polasek, O.; Kirin, M.; Hastie, N.D.; Wilson, J.F.; Rudan, I.; Campbell, H.; Vatavuk, Z.; Fleck, B. and Wright, A. New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.
    Hum.Mol.Genet. 19(21):4304-4311, 2010 PubMed Abstract
  60. Voight, B.F.; Scott, L.J.; Steinthorsdottir, V.; Morris, A.P.; Dina, C.; Welch, R.P.; Zeggini, E.; Huth, C.; Aulchenko, Y.S.; Thorleifsson, G.; McCulloch, L.J.; Ferreira, T.; Grallert, H.; Amin, N.; Wu, G.; Willer, C.J.; Raychaudhuri, S.; McCarroll, S.A.; Langenberg, C.; Hofmann, O.M.; Dupuis, J.; Qi, L.; Segre, A.V.; van Hoek, M.; Navarro, P.; Ardlie, K.; Balkau, B.; Benediktsson, R.; Bennett, A.J.; Blagieva, R.; Boerwinkle, E.; Bonnycastle, L.L.; Bengtsson, B.K.; Bravenboer, B.; Bumpstead, S.; Burtt, N.P.; Charpentier, G.; Chines, P.S.; Cornelis, M.; Couper, D.J.; Crawford, G.; Doney, A.S.; Elliott, K.S.; Elliott, A.L.; Erdos, M.R.; Fox, C.S.; Franklin, C.S.; Ganser, M.; Gieger, C.; Grarup, N.; Green, T.; Griffin, S.; Groves, C.J.; Guiducci, C.; Hadjadj, S.; Hassanali, N.; Herder, C.; Isomaa, B.; Jackson, A.U.; Johnson, P.R.; Jorgensen, T.; Kao, W.H.; Klopp, N.; Kong, A.; Kraft, P.; Kuusisto, J.; Lauritzen, T.; Li, M.; Lieverse, A.; Lindgren, C.M.; Lyssenko, V.; Marre, M.; Meitinger, T.; Midthjell, K.; Morken, M.A.; Narisu, N.; Nilsson, P.; Owen, K.R.; Payne, F.; Perry, J.R.; Petersen, A.K.; Platou, C.; Proenca, C.; Prokopenko, I.; Rathmann, W.; Rayner, N.W.; Robertson, N.R.; Rocheleau, G.; Roden, M.; Sampson, M.J.; Saxena, R.; Shields, B.M.; Shrader, P.; Sigurdsson, G.; Sparso, T.; Strassburger, K.; Stringham, H.M.; Sun, Q.; Swift, A.J.; Thorand, B.; Tichet, J.; Tuomi, T.; van Dam, R.M.; van Haeften, T.W.; van Herpt, T.; Vliet-Ostaptchouk, J.V.; Bragi, W.G.; Weedon, M.N.; Wijmenga, C.; Witteman, J.; Bergman, R.N.; Cauchi, S.; Collins, F.S.; Gloyn, A.L.; Gyllensten, U.; Hansen, T.; Hide, W.A.; Hitman, G.A.; Hofman, A.; Hunter, D.J.; Hveem, K.; Laakso, M.; Mohlke, K.L.; Morris, A.D.; Palmer, C.N.; Pramstaller, P.P.; Rudan, I.; Sijbrands, E.; Stein, L.D.; Tuomilehto, J.; Uitterlinden, A.; Walker, M.; Wareham, N.J.; Watanabe, R.M.; Abecasis, G.R.; Boehm, B.O.; Campbell, H.; Daly, M.J.; Hattersley, A.T.; Hu, F.B.; Meigs, J.B.; Pankow, J.S.; Pedersen, O.; Wichmann, H.E.; Barroso, I.; Florez, J.C.; Frayling, T.M.; Groop, L.; Sladek, R.; Thorsteinsdottir, U.; Wilson, J.F.; Illig, T.; Froguel, P.; van Duijn, C.M.; Stefansson, K.; Altshuler, D.; Boehnke, M. and McCarthy, M.I. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat.Genet. 42(7):579-589, 2010
    PubMed Abstract
  61. von Holst, S.; Picelli, S.; Edler, D.; Lenander, C.; Dalen, J.; Hjern, F.; Lundqvist, N.; Lindforss, U.; Pahlman, L.; Smedh, K.; Tornqvist, A.; Holm, J.; Janson, M.; Andersson, M.; Ekelund, S.; Olsson, L.; Ghazi, S.; Papadogiannakis, N.; Tenesa, A.; Farrington, S.M.; Campbell, H.; Dunlop, M.G. and Lindblom, A. Association studies on 11 published colorectal cancer risk loci. Br.J Cancer 103(4):575-580, 2010
    PubMed Abstract
  62. Walker, R.M.; Christoforou, A.; Thomson, P.A.; McGhee, K.A.; Maclean, A.; Muhleisen, T.W.; Strohmaier, J.; Nieratschker, V.; Nothen, M.M.; Rietschel, M.; Cichon, S.; Morris, S.W.; Jilani, O.; Stclair, D.; Blackwood, D.H.; Muir, W.J.; Porteous, D.J. and Evans, K.L. Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder. Neurosci.Lett. 478(1):9-13, 2010
    PubMed Abstract
  63. Walter, T.; Shattuck, D.; Baldock, R.; Bastin, M.; Carpenter, A.E.; Duce, S.; Ellenberg, J.; Fraser, A.; Hamilton, N.; Pieper, S.; Ragan, M.A.; Schneider, J.; Tomancak, P. and Heriche, J. Visualization of image data from cells to organisms. Nature Methods Supplement 7(3):S26-S41,
    2010 PubMed Abstract
  64. Wei, W.H.; Duan, Y.; Haley, C.S.; Ren, J.; De Koning, D.J. and Huang, L.S. High throughput analyses of epistasis for swine body dimensions and organ weights.
    Anim Genet. E-pub May 26, 2010
    PubMed Abstract
  65. Wei, W.H.; Knott, S.; Haley, C.S. and De Koning, D.J. Controlling false positives in the mapping of epistatic QTL
    Heredity     104(4):401-9, 2010
    PubMed Abstract
  66. Welman, A.; Serrels, A.; Brunton, V.G.; Ditzel, M. and Frame, M.C. Two-color photoactivatable probe for selective tracking of proteins and cells. J Biol Chem. 285(15):11607-11616, 2010 PubMed Abstract
  67. Worrall, E.G.; Worrall, L.; Blackburn, E.; Walkinshaw, M. and Hupp, T.R. The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2. J Mol.Biol 398(3):414-428, 2010
    PubMed Abstract
  68. Wright, A.F.; Chakarova, C.F.; Abd El-Aziz, M.M. and Bhattacharya, S.S. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait.
    Nat.Rev.Genet.     11(4):273-284, 2010
    PubMed Abstract
  69. Wright, A.F. and Dhillon, B. Major progress in Fuchs's corneal dystrophy.
    N.Engl.J Med 363(11):1072-1075, 2010
    PubMed Abstract
  70. Wright, A.F.; Rudan, I.; Hastie, N.D. and Campbell, H. A 'complexity' of urate transporters.
    Kidney Int.     78(5):446-452, 2010
    PubMed Abstract
  71. Yu-Wai-Man, P.; Griffiths, P.G.; Gorman, G.S.; Lourenco, C.M.; Wright, A.F.; Auer-Grumbach, M.; Toscano, A.; Musumeci, O.; Valentino, M.L.; Caporali, L.; Lamperti, C.; Tallaksen, C.M.; Duffey, P.; Miller, J.; Whittaker, R.G.; Baker, M.R.; Jackson, M.J.; Clarke, M.P.; Dhillon, B.; Czermin, B.; Stewart, J.D.; Hudson, G.; Reynier, P.; Bonneau, D.; Marques, W., Jr.; Lenaers, G.; McFarland, R.; Taylor, R.W.; Turnbull, D.M.; Votruba, M.; Zeviani, M.; Carelli, V.; Bindoff, L.A.; Horvath, R.; Amati-Bonneau, P. and Chinnery, P.F. Multi-system neurological disease is common in patients with OPA1 mutations. Brain 133(Pt 3):771-786, 2010 PubMed Abstract



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Publications 2010

  1. Aitken, S.J.; Thomas, J.S.; Langdon, S.P.; Harrison, D.J. and Faratian, D. Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases.
    Ann.Oncol.    21(6):1254-61, 2010
    PubMed Abstract
  2. Albagha, O.M.; Visconti, M.R.; Alonso, N.; Langston, A.L.; Cundy, T.; Dargie, R.; Dunlop, M.G.; Fraser, W.D.; Hooper, M.J.; Isaia, G.; Nicholson, G.C.; Del Pino, M.J.; Gonzalez-Sarmiento, R.; di Stefano, M.; Tenesa, A.; Walsh, J.P. and Ralston, S.H. Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
    Nat.Genet.     42(6):520-524,, 2010
    PubMed Abstract
  3. Arsava, E.M.; Ballabio, E.; Benner, T.; Cole, J.W.; Delgado-Martinez, M.P.; Dichgans, M.; Fazekas, F.; Furie, K.L.; Illoh, K.; Jood, K.; Kittner, S.; Lindgren, A.G.; Majersik, J.J.; Macleod, M.J.; Meurer, W.J.; Montaner, J.; Olugbodi, A.A.; Pasdar, A.; Redfors, P.; Schmidt, R.; Sharma, P.; Singhal, A.B.; Sorensen, A.G.; Sudlow, C.; Thijs, V.; Worrall, B.B.; Rosand, J. and Ay, H. The Causative Classification of Stroke system: an international reliability and optimization study.
    Neurology     75(14):1277-1284, 2010
    PubMed Abstract
  4. Baglietto, L.; Lindor, N.M.; Dowty, J.G.; White, D.M.; Wagner, A.; Gomez Garcia, E.B.; Vriends, A.H.; Cartwright, N.R.; Barnetson, R.A.; Farrington, S.M.; Tenesa, A.; Hampel, H.; Buchanan, D.; Arnold, S.; Young, J.; Walsh, M.D.; Jass, J.; Macrae, F.; Antill, Y.; Winship, I.M.; Giles, G.G.; Goldblatt, J.; Parry, S.; Suthers, G.; Leggett, B.; Butz, M.; Aronson, M.; Poynter, J.N.; Baron, J.A.; Le Marchand, L.; Haile, R.; Gallinger, S.; Hopper, J.L.; Potter, J.; de la, C.A.; Vasen, H.F.; Dunlop, M.G.; Thibodeau, S.N. and Jenkins, M.A. Risks of Lynch syndrome cancers for MSH6 mutation carriers
    J Natl.Cancer Inst. 102(3):193-201, 2010
    PubMed Abstract

  5. Beck-Nielsen, S.S.; Brusgaard, K.; Rasmussen, L.M.; Brixen, K.; Brock-Jacobsen, B.; Poulsen, M.R.; Vestergaard, P.; Ralston, S.H.; Albagha, O.M.; Poulsen, S.; Haubek, D.; Gjorup, H.; Hintze, H.; Andersen, M.G.; Heickendorff, L.; Hjelmborg, J. and Gram, J. Phenotype presentation of hypophosphatemic rickets in adults.
    Calcif.Tissue Int.     87(2):108-119, 2010
    PubMed Abstract

  6. Bovellan, M.; Fritzsche, M.; Stevens, C. and Charras, G. Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death
    FEBS Journall  277(1):58-65, 2010
    PubMed Abstract
  7. Bradshaw, N.J. and Porteous, D.J. DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology, e-pub Dec 31, 2010 PubMed Abstract
  8. Carrasquillo, M.M.; Belbin, O.; Zou, F.; Allen, M.; Ertekin-Taner, N.; Ansari, M.; Wilcox, S.L.; Kashino, M.R.; Ma, L.; Younkin, L.H.; Younkin, S.G.; Younkin, C.S.; Dincman, T.A.; Howard, M.E.; Howell, C.C.; Stanton, C.M.; Watson, C.M.; Crump, M.; Vitart, V.; Hayward, C.; Hastie, N.D.; Rudan, I.; Campbell, H.; Polasek, O.; Brown, K.; Passmore, P.; Craig, D.; McGuinness, B.; Todd, S.; Kehoe, P.G.; Mann, D.M.; Smith, A.D.; Beaumont, H.; Warden, D.; Holmes, C.; Heun, R.; Kolsch, H.; Kalsheker, N.; Pankratz, V.S.; Dickson, D.W.; Graff-Radford, N.R.; Petersen, R.C.; Wright, A.F.; Younkin, S.G. and Morgan, K. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    PLoS One. 5(1):e8764, 2010
    PubMed Abstract

  9. Christoforou, A.; McGhee, K.A.; Morris, S.W.; Thomson, P.A.; Anderson, S.; McLean, A.; Torrance, H.S.; Le Hellard, S.; Pickard, B.S.; Stclair, D.; Muir, W.J.; Blackwood, D.H.; Porteous, D.J. and Evans, K.L. Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p. Mol.Psychiatry e-pub march 30, 2010
    PubMed Abstract

  10. Cooke, S.L.; Ng, C.K.; Melnyk, N.; Garcia, M.J.; Hardcastle, T.; Temple, J.; Langdon, S.; Huntsman, D. and Brenton, J.D. Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma. Oncogene 29(35):4905-4913, 2010
    PubMed Abstract
  11. Court-Brown CM; Aitken, S.A.; Ralston, S.H. and McQueen, M.M. The relationship of fall-related fractures to social deprivation. Osteoporos.Int., 2010
    PubMed Abstract
  12. Cross, S.H.; McKie, L.; West, K.; Coghill, E.L.; Favor, J.; Bhattacharya, S.; Brown, S.D. and Jackson, I.J. The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype
    Hum.Mol.Genet. e-pub Oct 13, 2010
    PubMed Abstract
  13. De Cecco, M.; Seo, E.S.; Clarke, D.J.; McCullough, B.J.; Taylor, K.; MacMillan, D.; Dorin, J.R.; Campopiano, D.J. and Barran, P.E. Conformational preferences of linear beta-defensins are revealed by ion mobility-mass spectrometry.
    J Phys.Chem.B 114(6):2312-2318, 2010
    PubMed Abstract
  14. Delaney, A.; Keighren, M.; Fleetwood-Walker, S.M. and Jackson, I.J. Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin. PLoS One. 5(9):e12498, 2010
    PubMed Abstract
  15. Din, F.V.; Theodoratou, E.; Farrington, S.M.; Tenesa, A.; Barnetson, R.A.; Cetnarskyj, R.; Stark, L.; Porteous, M.E.; Campbell, H. and Dunlop, M.G. Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.
    Gut     59(12):1670-1679, 2010
    PubMed Abstract
  16. Dinour, D.; Gray, N.K.; Campbell, S.; Shu, X.; Sawyer, L.; Richardson, W.; Rechavi, G.; Amariglio, N.; Ganon, L.; Sela, B.A.; Bahat, H.; Goldman, M.; Weissgarten, J.; Millar, M.R.; Wright, A.F. and Holtzman, E.J. Homozygous SLC2A9 mutations cause severe renal hypouricemia.
    J Am.Soc.Nephrol.     21(1):64-72, 2010
    PubMed Abstract
  17. Dudnakova, T.; Spraggon, L.; Slight, J. and Hastie, N. Actin: a novel interaction partner of WT1 influencing its cell dynamic properties. Oncogene 29(7):1085-92, 2010
    PubMed Abstract
  18. Dupuis, J.; Langenberg, C.; ....Navarro, P.; .........Hayward, C.; ......... Vitart, V.; ...... Wright, A.F.:...........and Barroso, I. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    Nat.Genet.     42(2):105-116, 2010
    PubMed Absract
  19. Elks, C.E.; Perry, J.R.; ……. Hayward, C …….Navarro, P…….. Wright, A.F. and Murray, A. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    Nat.Genet.     42(12):1077-1085, 2010
    PubMed Abstract
  20. Eskeland, R.; Leeb, M.; Grimes, G.R.; Kress, C.; Boyle, S.; Sproul, D.; Gilbert, N.; Fan, Y.; Skoultchi, A.I.; Wutz, A. and Bickmore, W.A. Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.
    Mol.Cell 38(3):452-464, 2010
    PubMed Abstract
  21. Essafi, A. and Hastie, N.D. WT1 the Oncogene: A Tale of Death and HtrA.
    Mol.Cell     37(2):153-155, 2010
    PubMed Abstract
  22. Facheris, M.F.; Hicks, A.A.; Minelli, C.; Hagenah, J.M.; Kostic, V.; Campbell, S.; Hayward, C.; Volpato, C.B.; Pattaro, C.; Vitart, V.; Wright, A.; Campbell, H.; Klein, C. and Pramstaller, P.P. Variation in the Uric Acid Transporter Gene SLC2A9 and Its Association with AAO of Parkinson's Disease.
    J Mol.Neurosci.e-pub June 30, 2010
    PubMed Abstract
  23. Faull, P. A.; Florance, H. V.; Schmidt, C. Q.; Tomczyk, N.; Barlow, P. N.; Hupp, T. R.; Nikolova, P. V., and Barran, P. E. Utilising ion mobility-mass spectrometry to interrogate macromolecules: Factor H complement control protein modules 10–15 and 19–20 and the DNA-binding core domain of tumour suppressor p53. International Journal of Mass Spectrometry 2010
  24. Fong, P.C.; Yap, T.A.; Boss, D.S.; Carden, C.P.; Mergui-Roelvink, M.; Gourley, C.; De Greve, J.; Lubinski, J.; Shanley, S.; Messiou, C.; A'Hern, R.; Tutt, A.; Ashworth, A.; Stone, J.; Carmichael, J.; Schellens, J.H.; de Bono, J.S. and Kaye, S.B. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval.
    J Clin Oncol     28(15):2512-2519, 2010
    PubMed Abstract
  25. Frame, M.C.; Patel, H.; Serrels, B.; Lietha, D. and Eck, M.J. The FERM domain: organizing the structure and function of FAK.
    Nat.Rev.Mol.Cell Biol 11(11):802-814, 2010 PubMed Abstract
  26. Franklin, C.S.; Aulchenko, Y.S.; Huffman, J.E.; Vitart, V.; Hayward, C.; Polasek, O.; Knott, S.; Zgaga, L.; Zemunik, T.; Rudan, I.; Campbell, H.; Wright, A.F.; Wild, S.H. and Wilson, J.F. The TCF7L2 diabetes risk variant is associated with HbA(C) levels: a genome-wide association meta-analysis.
    Ann.Hum.Genet.     74(6):471-478, 2010
    PubMed Abstract
  27. Galeano, F.; Leroy, A.; Rossetti, C.; Gromova, I.; Gautier, P.; Keegan, L.P.; Massimi, L.; Di Rocco, C.; O'Connell, M.A. and Gallo, A. Human BLCAP transcript: New editing events in normal and cancerous tissues.
    Int.J Cancer 127(1):127-137, 2010
    PubMed Abstract
  28. Gourley, C.; Michie, C.O.; Roxburgh, P.; Yap, T.A.; Harden, S.; Paul, J.; Ragupathy, K.; Todd, R.; Petty, R.; Reed, N.; Hayward, R.L.; Mitchell, P.; Rye, T.; Schellens, J.H.; Lubinski, J.; Carmichael, J.; Kaye, S.B.; Mackean, M. and Ferguson, M. Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.
    J Clin Oncol     28(15):2505-2511, 2010
    PubMed Abstact
  29. Grabher, C.; Patton, E.E. and Strahle, U. Sharing chemical libraries within the European zebrafish community.
    Zebrafish.      7(1):83, 2010
    Pubmed Abstract
  30. Harewood, L.; Keeling, J.W.; Fantes, J.A.; Opitz, J.M. and Fitzpatrick, D.R. 'Crommelin-type' symmetrical tetramelic reduction deformity: a new case and breakpoint mapping of a reported case with de-novo t(2;12)(p25.1;q23.3).
    Clin.Dysmorphol.     19(1):5-13, 2010
    PubMed Abstract
  31. Harewood, L.; Liu, M.; Keeling, J.; Howatson, A.; Whiteford, M.; Branney, P.; Evans, M.; Fantes, J. and Fitzpatrick, D.R. Bilateral renal genesis/hypoplasia/dysplasia (BRAHD): postmortem analysis of 45 cases with breakpoint mapping of two de novo translocations. PLoS One. 5(8), 2010
    PubMed Abstract
  32. Harewood, L.; Schutz, F.; Boyle, S.; Perry, P.; Delorenzi, M.; Bickmore, W.A. and Reymond, A. The effect of translocation-induced nuclear reorganization on gene expression.
    Genome Res    , 20:554-564, 2010
    PubMed Abstract
  33. Heale, B. S.; Eulalio, A.; Schulte, L.; Vogel, J., and O'Connell, M. A. Analysis of A to I editing of miRNA in macrophages exposed to salmonella. RNA Biology 7(5):116-122, 2010
    PubMed Abstract
  34. Heid, I.M.; Jackson, A.U.; … Hayward, C.; …… Vitart, V.;…..Wright, A.F….. and Lindgren, C.M. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
    Nat.Genet.     42(11):949-960, 2010
    PubMed Abstract
  35. Holder, E.; Stevenson, B.; Farley, R.; Hilliard, T.; Wodehouse, T.; Somerton, L.; Larsen, M.; O'Donoghue, J.; Coles, R.L.; Scheule, R.K.; Cheng, S.H.; Gill, D.R.; Hyde, S.C.; Griesenbach, U.; Alton, E.W.; Porteous, D.J. and Boyd, A.C. Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity.
    J Gene Med 12(1):55-63, 2010
    PubMed Abstract
  36. Houlihan, L.M.; Davies, G.; Tenesa, A.; Harris, S.E.; Luciano, M.; Gow, A.J.; McGhee, K.A.; Liewald, D.C.; Porteous, D.J.; Starr, J.M.; Lowe, G.D.; Visscher, P.M. and Deary, I.J. Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
    Am.J Hum.Genet. 86(4):626-631, 2010 PubMed Abstract
  37. Houlihan, L.M.; Wyatt, N.D.; Harris, S.E.; Hayward, C.; Gow, A.J.; Marioni, R.E.; Strachan, M.W.; Price, J.F.; Starr, J.M.; Wright, A.F. and Deary, I.J. Variation in the uric acid transporter gene (SLC2A9) and memory performance.
    Hum.Mol.Genet.     19(11):2321-2330, 2010 PubMed Abstract
  38. Houlston, R.S.; Cheadle, J.; Dobbins, S.E.; Tenesa, A.; Jones, A.M.; Howarth, K.; Spain, S.L.; Broderick, P.; Domingo, E.; Farrington, S.; Prendergast, J.G.; Pittman, A.M.; Theodoratou, E.; Smith, C.G.; Olver, B.; Walther, A.; Barnetson, R.A.; Churchman, M.; Jaeger, E.E.; Penegar, S.; Barclay, E.; Martin, L.; Gorman, M.; Mager, R.; Johnstone, E.; Midgley, R.; Niittymaki, I.; Tuupanen, S.; Colley, J.; Idziaszczyk, S.; Thomas, H.J.; Lucassen, A.M.; Evans, D.G.; Maher, E.R.; Maughan, T.; Dimas, A.; Dermitzakis, E.; Cazier, J.B.; Aaltonen, L.A.; Pharoah, P.; Kerr, D.J.; Carvajal-Carmona, L.G.; Campbell, H.; Dunlop, M.G. and Tomlinson, I.P. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
    Nat.Genet. 42(11):973-977, 2010
    PubMed Abstract
  39. Hupp, T.R. Death-associated protein kinase (DAPK) and signal transduction
    FEBS Journal 277(1):47, 2010
    PubMed Abstract
  40. Idris, A.I.; Landao-Bassonga, E. and Ralston, S.H. The TRPV1 ion channel antagonist capsazepine inhibits osteoclast and osteoblast differentiation in vitro and ovariectomy induced bone loss in vivo. Bone 46(4):1089-1099, 2010 PubMed Abstract
  41. Igl, W.; Johansson, A.; Wilson, J.F.; Wild, S.H.; Polasek, O.; Hayward, C.; Vitart, V.; Hastie, N.; Rudan, P.; Gnewuch, C.; Schmitz, G.; Meitinger, T.; Pramstaller, P.P.; Hicks, A.A.; Oostra, B.A.; van Duijn, C.M.; Rudan, I.; Wright, A.; Campbell, H. and Gyllensten, U. Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.
    PLoS Genet.     6(1):e1000798, 2010
    PubMed Abstract
  42. Illingworth, R.S.; Gruenewald-Schneider, U.; Webb, S.; Kerr, A.R.; James, K.D.; Turner, D.J.; Smith, C.; Harrison, D.J.; Andrews, R. and Bird, A.P. Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet. 6(9), 2010
    PubMed Abstract
  43. Ishizaki, H.; Spitzer, M.; Wildenhain, J.; Anastasaki, C.; Zeng, Z.; Dolma, S.; Shaw, M.; Madsen, E.; Gitlin, J.; Marais, R.; Tyers, M. and Patton, E.E. Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation.
    Dis Model.Mech.     3(9-10):639-651, 2010 PubMed Abstract
  44. Jackson, C.A.; Hutchison, A.; Dennis, M.S.; Wardlaw, J.M.; Lindgren, A.; Norrving, B.; Anderson, C.S.; Hankey, G.J.; Jamrozik, K.; Appelros, P. and Sudlow, C.L. Differing risk factor profiles of ischemic stroke subtypes: evidence for a distinct lacunar arteriopathy? Stroke 41(4):624-629, 2010
    PubMed Abstract
  45. Johansson, A.; Marroni, F.; Hayward, C.; Franklin, C.S.; Kirichenko, A.V.; Jonasson, I.; Hicks, A.A.; Vitart, V.; Isaacs, A.; Axenovich, T.; Campbell, S.; Floyd, J.; Hastie, N.; Knott, S.; Lauc, G.; Pichler, I.; Rotim, K.; Wild, S.H.; Zorkoltseva, I.V.; Wilson, J.F.; Rudan, I.; Campbell, H.; Pattaro, C.; Pramstaller, P.; Oostra, B.A.; Wright, A.F.; van Duijn, C.M.; Aulchenko, Y.S. and Gyllensten, U. Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene.
    Obesity.(Silver.Spring)     18(4):803-8, 2010 PubMed Abstract
  46. Katz, E.; Dubois-Marshall, S.; Sims, A.H.; Faratian, D.; Li, J.; Smith, E.S.; Quinn, J.A.; Edward, M.; Meehan, R.R.; Evans, E.E.; Langdon, S.P. and Harrison, D.J. A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk.
    Br.J Cancer     103(3):401-410, 2010
    PubMed Abstract
  47. Kerr, E.; Kiyuna, T.; Boyle, S.; Saito, A.; Thomas, J.S. and Bickmore, W.A. Changes in chromatin structure during processing of wax-embedded tissue sections.
    Chromosome Res     18(6):677-688, 2010
    PubMed Abstract
  48. Kerwin, J.; Yang, Y.; Merchan, P.; Sarma, S.; Thompson, J.; Wang, X.; Sandoval, J.; Puelles, L.; Baldock, R. and Lindsay, S. The HUDSEN Atlas: a three-dimensional (3D) spatial framework for studying gene expression in the developing human brain.
    J Anat.     217(4):289-299, 2010
    PubMed Abstract
  49. Kestenbaum, B.; Glazer, N.L.;…. Hayward, C….and Fox, C.S. Common genetic variants associate with serum phosphorus concentration. Journal Of The American Society Of Nephrology 21(7):1223-1232, 2010
    PubMed Abstract
  50. Kirschner, K. and Melton, D.W. Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs.
    Anticancer Res     30(9):3223-3232, 2010
    PubMed Abstract
  51. Kitchen, R.R.; Sabine, V.S.; Sims, A.H.; Macaskill, E.J.; Renshaw, L.; Thomas, J.S.; van Hemert, J.I.; Dixon, J.M. and Bartlett, J.M. Correcting for intra-experiment variation in Illumina BeadChip data is necessary to generate robust gene-expression profiles.
    BMC Genomics     11:134, 2010
    PubMed Abstract
  52. Knezevic, A.; Gornik, O.; Polasek, O.; Pucic, M.; Redzic, I.; Novokmet, M.; Rudd, P.M.; Wright, A.F.; Campbell, H.; Rudan, I. and Lauc, G. Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans. Glycobiology 20(8):959-969, 2010 PubMed Abstract
  53. Kocanova, S.; Kerr, E.A.; Rafique, S.; Boyle, S.; Katz, E.; Caze-Subra, S.; Bickmore, W.A. and Bystricky, K. Activation of estrogen-responsive genes does not require their nuclear co-localization.
    PLoS Genet. 6(4):e1000922, 2010
    PubMed Abstract
  54. Kottgen, A.; Pattaro, C.; Boger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; Li, M.; Schmidt, H.; Tanaka, T.; Isaacs, A.; Ketkar, S.; Hwang, S.J.; Johnson, A.D.; Dehghan, A.; Teumer, A.; Pare, G.; Atkinson, E.J.; Zeller, T.; Lohman, K.; Cornelis, M.C.; Probst-Hensch, N.M.; Kronenberg, F.; Tonjes, A.; Hayward, C.; Aspelund, T.; Eiriksdottir, G.; Launer, L.J.; Harris, T.B.; Rampersaud, E.; Mitchell, B.D.; Arking, D.E.; Boerwinkle, E.; Struchalin, M.; Cavalieri, M.; Singleton, A.; Giallauria, F.; Metter, J.; de Boer, I.H.; Haritunians, T.; Lumley, T.; Siscovick, D.; Psaty, B.M.; Zillikens, M.C.; Oostra, B.A.; Feitosa, M.; Province, M.; de Andrade, M.; Turner, S.T.; Schillert, A.; Ziegler, A.; Wild, P.S.; Schnabel, R.B.; Wilde, S.; Munzel, T.F.; Leak, T.S.; Illig, T.; Klopp, N.; Meisinger, C.; Wichmann, H.E.; Koenig, W.; Zgaga, L.; Zemunik, T.; Kolcic, I.; Minelli, C.; Hu, F.B.; Johansson, A.; Igl, W.; Zaboli, G.; Wild, S.H.; Wright, A.F.; Campbell, H.; Ellinghaus, D.; Schreiber, S.; Aulchenko, Y.S.; Felix, J.F.; Rivadeneira, F.; Uitterlinden, A.G.; Hofman, A.; Imboden, M.; Nitsch, D.; Brandstatter, A.; Kollerits, B.; Kedenko, L.; Magi, R.; Stumvoll, M.; Kovacs, P.; Boban, M.; Campbell, S.; Endlich, K.; Volzke, H.; Kroemer, H.K.; Nauck, M.; Volker, U.; Polasek, O.; Vitart, V.; Badola, S.; Parker, A.N.; Ridker, P.M.; Kardia, S.L.; Blankenberg, S.; Liu, Y.; Curhan, G.C.; Franke, A.; Rochat, T.; Paulweber, B.; Prokopenko, I.; Wang, W.; Gudnason, V.; Shuldiner, A.R.; Coresh, J.; Schmidt, R.; Ferrucci, L.; Shlipak, M.G.; van Duijn, C.M.; Borecki, I.; Kramer, B.K.; Rudan, I.; Gyllensten, U.; Wilson, J.F.; Witteman, J.C.; Pramstaller, P.P.; Rettig, R.; Hastie, N.; Chasman, D.I.; Kao, W.H.; Heid, I.M. and Fox, C.S. New loci associated with kidney function and chronic kidney disease.
    Nat.Genet.     42(5):376-384, 2010
    PubMed Abstract
  55. Lango, A.H.; Estrada, K….. Hayward, C.;…. Vitart, V.; …….; Wright, A.F…. and Ouwehand, W.H. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467(7317):832-838, 2010
    PubMed Abstract
  56. Langston, A.L.; Campbell, M.K.; Fraser, W.D.; MacLennan, G.S.; Selby, P.L. and Ralston, S.H. Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone.
    J Bone Miner.Res     25(1):20-31, 2010
    PubMed Abstract
  57. Lauc, G.; Essafi, A.; Huffman, J.E.; Hayward, C.; Knezevic, A.; Kattla, J.J.; Polasek, O.; Gornik, O.; Vitart, V.; Abrahams, J.L.; Pucic, M.; Novokmet, M.; Redzic, I.; Campbell, S.; Wild, S.H.; Borovecki, F.; Wang, W.; Kolcic, I.; Zgaga, L.; Gyllensten, U.; Wilson, J.F.; Wright, A.F.; Hastie, N.D.; Campbell, H.; Rudd, P.M. and Rudan, I. Genomics Meets Glycomics-The First GWAS Study of Human N-Glycome Identifies HNF1alpha as a Master Regulator of Plasma Protein Fucosylation.
    PLoS Genet. 6(12):e1001256, 2010
    PubMed Abstract
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